tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate - Names and Identifiers
Name | N-Boc-D-2-piperidinecarboxamide
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Synonyms | N-Boc-D-2-piperidinecarboxamide (R)-1-Boc-2-piperidinecarboxaMide (R)-1-Boc-2-(aminocarbonyl)piperidine (R)-tert-butyl 2-carbamoylpiperidine-1-carboxylate tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate tert-butyl (2R)-2-carbamoylpiperidine-1-carboxylate (R)-tert-Butyl 2-carbamoyllpiperidine-1-carboxylate (R)-2-Carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-
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CAS | 848488-91-5
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InChI | InChI=1/C11H20N2O3/c1-11(2,3)16-10(15)13-7-5-4-6-8(13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14)/t8-/m1/s1 |
tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate - Physico-chemical Properties
Molecular Formula | C11H20N2O3
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Molar Mass | 228.29 |
Density | 1.123g/cm3 |
Boling Point | 384.4°C at 760 mmHg |
Flash Point | 186.3°C |
Vapor Presure | 4.1E-06mmHg at 25°C |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.498 |
tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate - Introduction
N-Boc-D-2-piperidinecarboxamide(N-Boc-D-2-piperidinecarboxamide) is an organic compound. Its chemical formula is C12H20N2O3 and its molecular weight is 240.30g/mol. The following is a description of its nature, use, preparation and safety information:
Nature:
N-Boc-D-2-piperidinecarboxamide is a white to yellowish solid, soluble in some organic solvents such as dimethylformamide (DMF), benzene and ethanol. It is relatively stable at room temperature, but should avoid prolonged exposure to light and air.
Use:
N-Boc-D-2-piperidinecarboxamide is an important intermediate in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs with antiepileptic activity. In addition, it can also be used as a chiral inducer for the synthesis of chiral compounds, as well as the introduction of piperidine structures in the field of pharmaceutical research and organic synthesis.
Preparation Method:
The synthesis of N-Boc-D-2-piperidinecarboxamide usually uses simple chemical reaction methods. A common synthetic method is the condensation of 2-piperidinecarboxamide and N-tert-butoxycarbonyl-L-alanine via an amide bond binding reaction. The reaction may be carried out under basic conditions under an inert atmosphere. Finally, through crystallization and purification steps, the target product can be obtained.
Safety Information:
When using and handling N-Boc-D-2-piperidinecarboxamide, pay attention to the following safety precautions:
1. avoid contact with skin and eyes, avoid inhaling its dust or vapor.
2. When handling, appropriate protective measures should be used, such as wearing protective glasses, laboratory gloves and laboratory coats.
3. The safety data sheet (MSDS) of the chemical should be read and understood carefully before use.
4. storage should be sealed and placed in a dry, cool, well-ventilated place, away from flammable and oxidizing agents.
Last Update:2024-04-09 21:00:56